Ingredient Research

INTELLEKT™ EVIDENCE LIBRARY

WE RATE THE INGREDIENTS.
NOT THE HYPE.

Most supplement brands only talk about what they put in. We evaluate the whole industry against the evidence — what earns a place in an INTELLEKT formula, what’s still unproven, and what the marketing got ahead of. When the data disagrees, we side with the data.

HOW WE RATE

Three verdicts. One standard.

We weight our verdicts toward meta-analyses and systematic reviews over single trials. A promising mechanism or one positive study is a starting point, not a green light.

Recommended

Strong, repeated human evidence. These earn a place in our formulas.

Promising

Real potential, but the evidence is still thin or early. We use these carefully and say so.

Not Recommended

The marketing outran the science. No meaningful human evidence, so we leave them out.

Strength / Power Recommended

Creatine Monohydrate

The most researched sports-nutrition ingredient there is. Consistent human evidence for strength, power, and lean mass, backed by an ISSN position stand.

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Pump / Blood Flow Recommended

L-Citrulline

Supports nitric oxide, blood flow, and training pumps when dosed to the research (6g+). A pump-formula staple for good reason.

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Endurance Recommended

Beta-Alanine

Raises muscle carnosine to buffer fatigue in high-intensity work. Supported by an ISSN position stand. The tingle is harmless and temporary.

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Power / Output Recommended

Betaine Anhydrous

An osmolyte studied for strength, power, and training output at a 2.5g dose.

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Energy / Focus Recommended

Caffeine

The most reliable ergogenic aid in sports nutrition for energy, alertness, and performance. Backed by an ISSN position stand. Dose to tolerance.

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Focus / Calm Recommended

L-Theanine

Pairs with caffeine to smooth the stimulant curve and support steady focus without adding to the jitter.

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Focus Under Stress Recommended

L-Tyrosine

An amino acid studied for maintaining focus and mental output under demanding, high-stress training.

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Performance / Hydration Recommended

Taurine

Supports endurance and cellular hydration, and shows up across well-built performance formulas.

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Pump / Blood Flow · Branded Recommended

Nitrosigine®

A patented inositol-stabilized arginine silicate studied in RCTs for raising nitric oxide and blood flow around training.

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Pump / Blood Flow · Branded Recommended

VasoDrive-AP®

Milk-derived lactotripeptides (IPP/VPP) studied for vascular support and blood flow, with meta-analysis backing on the vascular side.

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Recovery / Lean Mass Recommended

HMB

A leucine metabolite studied for reducing exercise-induced muscle breakdown and preserving lean mass. Covered by a 2025 ISSN position stand.

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Hydration Recommended

Electrolytes

Sodium, potassium, and magnesium are fundamental to hydration, fluid balance, and performance in sweat-heavy training.

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Recovery / Immune Recommended

Vitamin C

A water-soluble antioxidant supporting exercise recovery and normal immune function.

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Muscle / Performance Recommended

Vitamin D3

Adequate vitamin D status is linked to muscle function and strength, with research focused on athletes.

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Energy Metabolism Recommended

Vitamin B6

A cofactor in energy metabolism, amino-acid metabolism, and neurotransmitter synthesis.

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Energy / Red Blood Cells Recommended

Vitamin B12

Supports normal energy metabolism, red blood cell formation, and nervous-system function.

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Choline Source Promising

Alpha-GPC

A highly bioavailable choline source. The human data on power output is early and small-sample, so we use it at a measured dose rather than overselling it.

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Cholinergic Support Promising

Huperzine A

Works by slowing the breakdown of acetylcholine. The mechanism is sound, but long-term human data in a training context is limited, so it earns a measured role, not a headline.

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Citicoline · Branded Promising

Cognizin®

A patented citicoline studied in RCTs for attention and memory. The evidence is real, but it sits in cognition research rather than training performance, so we keep our claims narrow.

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Energy / Mood Promising

Theobromine

A gentler, longer-acting cousin of caffeine. There’s some supportive data, but the effects are modest, so we treat it as a complement rather than a driver.

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Pump / Hydration · Branded Promising

HydroPrime® Glycerol

Effective for hyperhydration and fuller pumps. The tradeoff is practical, not scientific: glycerol powder attracts moisture and can clump, so we weigh formulation quality against the benefit.

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Recovery / MPS · Branded Promising

PeptiStrong®

A fenugreek-derived peptide with promising early human data for muscle protein synthesis and recovery. The evidence base is still small and the raw-material cost is high, so for now we’d rather invest those dollars in ingredients with deeper support.

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Marketed: Muscle Growth Not Recommended

Turkesterone

An ecdysteroid (a plant compound) sold as a natural muscle-builder. The anabolic hype traces back to cell and rodent studies — and the human trials that do exist showed no measurable effect on muscle, strength, or body composition. Without meaningful human evidence, it doesn’t meet our bar, so we don’t use it.

Marketed: Muscle Growth Not Recommended

Ecdysterone

A plant steroid pitched as a “natural anabolic.” The excitement rests on one small human study plus animal and cell data — not a replicated body of evidence. On top of that, testing has repeatedly found supplements that don’t contain the ecdysterone they claim. Until the human results are reproduced at scale and the raw material can be trusted, it doesn’t meet our bar.

Marketed: Recovery / Growth Not Recommended

Deer Antler Velvet

Sold for recovery and muscle growth on the premise that it delivers IGF-1. Controlled human trials haven’t shown meaningful performance or body-composition benefits, and any IGF-1 taken orally is broken down in digestion. It’s also flagged by anti-doping bodies. No real upside, real downside — so we skip it.

Sold Standalone Not Recommended

BCAAs (as a standalone product)

The amino acids themselves matter — but sold on their own, BCAAs are largely redundant. To build muscle you need the full set of essential amino acids, which a normal protein intake already provides. Spending on standalone BCAAs buys little that whole protein or EAAs don’t already cover, so we don’t build around them.

Marketed: Performance Not Recommended

Exotic Mushroom Performance Blends

Cordyceps, lion’s mane, and similar mushrooms are interesting compounds, but the human evidence for gym performance, strength, or endurance is thin and inconsistent, and blends rarely disclose meaningful doses. We’d rather wait for real data than sell hope in a proprietary blend.

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Verdicts reflect our reading of the available evidence and our formulation philosophy; they are educational and are not medical advice. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Always follow the product label and consult a qualified healthcare professional before use.

SEE IT ON THE LABEL

Formulas that read like this page.

Every INTELLEKT product is fully disclosed, clinically dosed, and built from ingredients that earn their place. No blends, no fillers, no hype.

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